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Synvisc® is for intra-articular injection only. Synvisc® contains small amounts of avian (chicken) protein and should not be used in patients with related hypersensitivities. Adverse events involving the injected joint: transient pain and/or swelling and/or effusion may occur after intra-articular injections of Synvisc®. The post-marketing experience has identified the following systemic events to occur rarely with Synvisc® administration: rash, hives, itching, fever, nausea, headache, dizziness, chills, muscle cramps, paresthesia, peripheral odema, malaise, respiratory difficulties, flushing and facial swelling.
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